HSV-1 causes about 43% of herpes located in the genital area.Both HSV-1 and HSV-2 can affect either the oral or genital area.Ĭommonly, HSV-1 affects the oral area and HSV-2 affects the genital area (that’s where their nicknames came from). HSV-1 means the oral area is affected and HSV-2 means the genital area is affected